Study on the association between the gene polymorphisms of TBX21 and rheumatoid arthritis

Objective:To investigate the relationship between the single nucleotide polymorphisms (SNPs) of TBX21 gene and rheumatoid arthritis (RA) in Chinese Han population.Methods:The SNPs of TBX21 gene (rs4794067,rs2240017,rs17250932,rs2074190 and rs12721470) in 288 patients with RA and 288 healthy controls were determined,and the relationship between TBX21gene SNPs and the patients with RA SNPs genotyping were performed by a method of Single Base Extension (SBE).Results:All the genotype frequencies of these SNPs were in Hardy-Weinberg equilibrium (HWE) (P0.05).The genotype and allele frequencies of rs12721470 polymorphism in the RA patients were significantly different from those of the healthy control group.The genotype frequencies of rs4794067 were not significant between patients with RA and healthy controls,but allele frequencies of the rs4794067 polymorphism were significantly (P0.05).There were not significant differences in genotypes and allele frequency distribution of rs17250932,rs2240017 and rs2074190 between patients with RA and healthy controls (P0.05).Conclusion:TBX21 polymorphisms at rs12721470 analyzed in the present study are the susceptible genes for rheumatoid arthritis (RA) in Chinese Han ethnicity.