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2021•Journal of Histology and HistopathologyOpen access

The role of eosinophils in necrosis mainly in single-system Langerhans cell histiocytosis

Yoshinori Kawabata, Nobukazu Tomichi, Mishie Tanino, Takashi Ogura, Masashi Kawamoto, Yasutsugu Fukushima, Kazuyoshi Kurashima, Yoshihiko Shimizu

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Abstract

Introduction Langerhans cell histiocytosis (LCH) integrates eosinophilic granuloma, Hand-Schüller-Christian disease, and Letterer- Siwe disease due to the proliferation of histiocyte-like cells, which have now been proved to be Langerhans cells [1,2]. The BRAF V600E mutation is an important genetic factor in LCH [3], and new terminology (inflammatory myeloid neoplasia) was introduced

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Introduction Langerhans cell histiocytosis (LCH) integrates eosinophilic granuloma, Hand-Schüller-Christian disease, and Letterer- Siwe disease due to the proliferation of histiocyte-like cells, which have now been proved to be Langerhans cells [1,2]. The BRAF V600E mutation is an important genetic factor in LCH [3], and new terminology (inflammatory myeloid neoplasia) was introduced

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Available abstract

Introduction Langerhans cell histiocytosis (LCH) integrates eosinophilic granuloma, Hand-Schüller-Christian disease, and Letterer- Siwe disease due to the proliferation of histiocyte-like cells, which have now been proved to be Langerhans cells [1,2]. The BRAF V600E mutation is an important genetic factor in LCH [3], and new terminology (inflammatory myeloid neoplasia) was introduced

Key concepts: Langerhans cell histiocytosis, Eosinophilic granuloma, Histiocyte, Histiocytosis, Pathology, Langerhans cell, Eosinophilic, Myeloid

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