The subiculum sensitizes retrosplenial cortex layer 2/3 pyramidal neurons

The retrosplenial cortex (RSC) is a cortical area that connects various brain regions and relays diverse neural information. Based on its unique connectivity, the RSC has been reported to be involved in a range of cognitive functions, including spatial navigation, episodic memory, sensory information processing and imagination of future events (Vann et al., 2003; Vann et al., 2009; Czajkowski et al., 2014). Recent studies suggested that the RSC communicates hippocampal information to the neocortex during sharp-wave ripples (SWRs), highly synchronous oscillatory events associated with memory consolidation during behavioral immobility and non-REM sleep (Nitzan et al., 2020; Opalka et al., 2020). However, the basic electrophysiological nature of RSC neurons remains to be elucidated.