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2020•PubMedRequires access

[Toxic effects of Vitamin C combined with temozolomide on glioma cells and its mechanism].

Mingsheng Chen, Haikang Zhao, Yingying Cheng, Zhihai Yuan, Yuelin Zhang

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Abstract

VC combined with temozolomide can enhance the toxicity of glioma cells. This effect is to promote apoptosis and inhibit temozolomide-mediated autophagy through the regulation of the ERK signaling pathway.

About this research paper

What this paper is about

VC combined with temozolomide can enhance the toxicity of glioma cells. This effect is to promote apoptosis and inhibit temozolomide-mediated autophagy through the regulation of the ERK signaling pathway.

Why it matters

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Key contribution

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Method / approach

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Main findings

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Available abstract

VC combined with temozolomide can enhance the toxicity of glioma cells. This effect is to promote apoptosis and inhibit temozolomide-mediated autophagy through the regulation of the ERK signaling pathway.

Key concepts: Apoptosis, Temozolomide, Annexin, Glioma, Western blot, Flow cytometry, Autophagy, MTT assay

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[Toxic effects of Vitamin C combined with temozolomide on glioma cells and its mechanism]. — Research Paper | ScholarLens