2021•Journal of Materials Chemistry BOpen access

Hyaluronic acid drives mesenchymal stromal cell-derived extracellular matrix assembly by promoting fibronectin fibrillogenesis

Marisa Assunção, Chi Him Kendrick Yiu, Ho-Ying Wan, Dan Michelle Wang, Dai Fei Elmer Ker, Rocky S. Tuan, Anna Maria Blocki

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Abstract

Hyaluronic acid (HA) is present at sites of ongoing fibronectin fibrillogenesis (fibrillar adhesions) and necessary for efficient fibronectin fibrillogenesis. As a result, fibronectin deposition can be enhanced by exogenous HA.

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Key concepts: Fibrillogenesis, Fibronectin, Hyaluronic acid, Extracellular matrix, Mesenchymal stem cell, Chemistry, Biophysics, Fibronectins