P0646 / #1927: THE ROLE OF ANGIOPOIETIN IN PAEDIATRIC SEPSIS

Aims & Objectives: Sepsis is a life-threatening organ dysfunction caused by dysregulation of host response to infection, and is still a global health problem due to high morbidity and mortality. The pathophysiology of sepsis and septic shock is complex and still not fully understood, but dysregulation of the systemic inflammatory response and endothelial dysfunction is thought to play an important role. One of the biomarkers of endothelial dysfunction is angiopoietin-1 and angiopoietin-2, which in conditions of injury, hypoxia such as in sepsis occurs an imbalance of the Ang-1 and Ang-2. The study aimed to find out the corelation of Angiopoietin and the outcome in pediatric sepsis. Methods: This is an analytical correlational cross sectional study of 83 subjects of sepsis aged 1-18 years in Hasan Sadikin General Hospital during the July-December 2019. Angiopoietin was assesed in all subjects at hospital admission. Statistical analysis using Mann Whitney, and Spearman rank correlation test, with p <0.05 was considered significant. Results: Angiopoietin-1 and angiopoietin-2 are significantly difference between survivor and non survivor group. Angiopoietin-2 was higher in non survivor group (3596 pg/ml vs 2192 pg/ml, p 0,042), and angiopoietin-1 was lower in non survivor group (26,56 pg/ml vs 12,94 pg/ml;p 0,024). Angiopoietin-1, angiopoietin-2, and ang-2/ang-1 ratio are correlated with mortality (r: 0,225, p 0,020; r:0,216,p 0,025; r:0,379, p 0,021). Conclusions: Angiopoietin 2 was higher in non survivor grup, and correlated with hospital mortality.