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2021•Infectious Microbes & DiseasesOpen access

Metabolic Regulation of the NLRP3 Inflammasome

Qizhen Ye, Sheng Chen, Di Wang

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Abstract

Abstract The progression of many diseases is accompanied by inflammation, in which inflammasomes play an important role. Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells, which mediate the activation of caspase-1 and the secretion of cytokines, leading to cellular pyroptosis. During this process, metabolic regulation of the inflammasome is gaining increasing attention in this field. This review focuses on a major inflammasome, NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), and discusses the role and significance of its metabolic regulation.

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What this paper is about

Abstract The progression of many diseases is accompanied by inflammation, in which inflammasomes play an important role. Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells, which mediate the activation of caspase-1 and the secretion of cytokines, leading to cellular pyroptosis. During this process, metabolic regulation of the inflammasome is gaining increasing attention in this field. This review focuses on a major inflammasome, NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), and discusses the role and significance of its metabolic regulation.

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Available abstract

Abstract The progression of many diseases is accompanied by inflammation, in which inflammasomes play an important role. Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells, which mediate the activation of caspase-1 and the secretion of cytokines, leading to cellular pyroptosis. During this process, metabolic regulation of the inflammasome is gaining increasing attention in this field. This review focuses on a major inflammasome, NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), and discusses the role and significance of its metabolic regulation.

Key concepts: Inflammasome, Pyroptosis, Pyrin domain, Secretion, Inflammation, Nod, Cell biology, Caspase 1

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