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2021•PubMedOpen access

[The role of CD146 in mesenchymal stem cells].

Kangkang Zha, Guangzhao Tian, Zhen Yang, Zhiqiang Sun, Shuyun Liu, Quanyi Guo

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Abstract

OBJECTIVE: To summarize the expression and role of CD146 in mesenchymal stem cells (MSCs). METHODS: The literature related to CD146 at home and abroad were extensively consulted, and the CD146 expression in MSCs and its function were summarized and analyzed. RESULTS: MSCs in the treatment of specific diseases has also achieved better results. CD146 is also involved in mediating a variety of cellular signaling pathways, but whether it plays the same role in MSCs remains to be demonstrated by further experiments. CONCLUSION: MSCs for tissue regeneration will be conducive to improving the therapeutic effect of MSCs.

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What this paper is about

OBJECTIVE: To summarize the expression and role of CD146 in mesenchymal stem cells (MSCs). METHODS: The literature related to CD146 at home and abroad were extensively consulted, and the CD146 expression in MSCs and its function were summarized and analyzed. RESULTS: MSCs in the treatment of specific diseases has also achieved better results. CD146 is also involved in mediating a variety of cellular signaling pathways, but whether it plays the same role in MSCs remains to be demonstrated by further experiments. CONCLUSION: MSCs for tissue regeneration will be conducive to improving the therapeutic effect of MSCs.

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Available abstract

OBJECTIVE: To summarize the expression and role of CD146 in mesenchymal stem cells (MSCs). METHODS: The literature related to CD146 at home and abroad were extensively consulted, and the CD146 expression in MSCs and its function were summarized and analyzed. RESULTS: MSCs in the treatment of specific diseases has also achieved better results. CD146 is also involved in mediating a variety of cellular signaling pathways, but whether it plays the same role in MSCs remains to be demonstrated by further experiments. CONCLUSION: MSCs for tissue regeneration will be conducive to improving the therapeutic effect of MSCs.

Key concepts: CD146, Mesenchymal stem cell, Cell biology, Immunology, Stem cell, Biology, CD34

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