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2017•Evidence-Based PracticeRequires access

What are the most effective pharmacologic treatments for adults with chronic primary insomnia?

Vanessa Rivera, Ruben Salinas

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Abstract

EVIDENCE-BASED ANSWER Benzodiazepines (particularly triazolam for 1 week) and nonbenzodiazepine hypnotic agents (particularly zolpidem and zopiclone for 2–5 weeks) modestly improve sleep-onset latency and subjective sleep reporting (SOR: B, meta-analysis of RCTs with publication bias and heterogeneity). Ramelteon does not improve sleep-onset latency or subjective sleep reporting to a clinically significant extent (SOR: B, meta-analysis of low quality RCTs).

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What this paper is about

EVIDENCE-BASED ANSWER Benzodiazepines (particularly triazolam for 1 week) and nonbenzodiazepine hypnotic agents (particularly zolpidem and zopiclone for 2–5 weeks) modestly improve sleep-onset latency and subjective sleep reporting (SOR: B, meta-analysis of RCTs with publication bias and heterogeneity). Ramelteon does not improve sleep-onset latency or subjective sleep reporting to a clinically significant extent (SOR: B, meta-analysis of low quality RCTs).

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Available abstract

EVIDENCE-BASED ANSWER Benzodiazepines (particularly triazolam for 1 week) and nonbenzodiazepine hypnotic agents (particularly zolpidem and zopiclone for 2–5 weeks) modestly improve sleep-onset latency and subjective sleep reporting (SOR: B, meta-analysis of RCTs with publication bias and heterogeneity). Ramelteon does not improve sleep-onset latency or subjective sleep reporting to a clinically significant extent (SOR: B, meta-analysis of low quality RCTs).

Key concepts: Zolpidem, Zopiclone, Sleep onset latency, Triazolam, Insomnia, Primary Insomnia, Hypnotic, Medicine

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What are the most effective pharmacologic treatments for adults with chronic primary insomnia? — Research Paper | ScholarLens