2019•International Journal of Dermatology Venereology and Leprosy SciencesOpen access
Assessment of efficacy of methotrexate and acitretin in the management of psoriasis
Roohi Sharma, Reeta Gupta, Pavan Malhotra
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Abstract
Background: Psoriasis is a chronic inflammatory skin disease characterized by a prominent T-cell infiltrate, epidermal hyper proliferation and abnormal keratinocyte differentiation. The present study was conducted to assess efficacy of methotrexate and acitretin in the management of psoriasis.Materials & Methods: 72 patients diagnosed with palmoplantar psoriasis were divided into 2 groups of 36 each. Group I patients were prescribed oral methotrexate15mg/week for 3 months and group II were given oral acitretin 0.5 mg/kg daily for 3 months. Modified psoriasis area severity index (MPASI) score was assessed.Results: There were 16 males and 20 females in group I and 18 males and 18 females in group II. The mean MASI score at baseline, 1 month, 2 months and 3 months was 58.2, 38.4, 23.2 and 14.6 and 60.4, 40.2, 30.5 and 20.4 in group I and II respectively. The difference was significant (P
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