2021•bioRxiv (Cold Spring Harbor Laboratory)Open access
Neuroprotective and Mitoprotective Effects of Lemon IntegroPectin on SH-SY5Y Cells
Domenico Nuzzo, Pasquale Picone, Costanza Giardina, Miriana Scordino, Giuseppa Mudò, Mario Pagliaro, Antonino Scurria, Francesco Meneguzzo, Laura M. Ilharco, Alexandra M. Fidalgo, Alessandro Presentato, Rosa Alduina, Rosaria Ciriminna, Valentina Di Liberto
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Abstract
Abstract Lemon IntegroPectin obtained via hydrodynamic cavitation of organic lemon processing waste in water shows significant neuroprotective activity in vitro , as first reported in this study investigating the effects of both lemon IntegroPectin and commercial citrus pectin on cell viability, cell morphology, reactive oxygen species (ROS) production and mitochondria perturbation induced by treatment of neuronal SH-SY5Y human cells with H 2 O 2 . Mediated by ROS including H 2 O 2 and its derivatives, oxidative stress alters numerous cellular processes, including mitochondrial regulation and cell signaling, propagating cellular injury that leads to incurable neurodegenerative diseases. These results, and the absence of toxicity of this new pectic substance rich in adsorbed flavonoids and terpenes, support further investigations to verify its activity in preventing, retarding, or even curing neurological diseases.
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