2021•mSphereOpen access

APEX2 Proximity Proteomics Resolves Flagellum Subdomains and Identifies Flagellum Tip-Specific Proteins in Trypanosoma brucei

Daniel E. Vélez‐Ramírez, Michelle M. Shimogawa, Sunayan S. Ray, Andrew Lopez, Shima Rayatpisheh, Gerasimos Langousis, Marcus Gallagher-Jones, Samuel Dean, James A. Wohlschlegel, Kent L. Hill

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Abstract

Sleeping sickness is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei . The disease disrupts the sleep-wake cycle, leading to coma and death if left untreated. T. brucei motility, transmission, and virulence depend on its flagellum (cilium), which consists of several different specialized subdomains.

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Key concepts: Flagellum, Trypanosoma brucei, Cilium, Motility, Virulence, Biology, Motile cilium, Transmission (telecommunications)