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2021•bioRxiv (Cold Spring Harbor Laboratory)Open access

Neutralization of UK-variant VUI-202012/01 with COVAXIN vaccinated human serum

Gajanan Sapkal, Pragya D. Yadav, Raches Ella, Gururaj Deshpande, Rima R. Sahay, Nivedita Gupta, Viswanathan Mohan, Priya Abraham, Samiran Panda, Balram Bhargava

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Abstract

Abstract We performed the plaque reduction neutralization test (PRNT 50 ) using sera collected from the recipients of BBV152/COVAXIN™ against hCoV-19/India/20203522 (UK-variant) and hCoV27 19/India/2020Q111 (heterologous strain). A comparable neutralization activity of the vaccinated individuals sera showed against UK-variant and the heterologous strain with similar efficiency, dispel the uncertainty of possible neutralization escape.

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Abstract We performed the plaque reduction neutralization test (PRNT 50 ) using sera collected from the recipients of BBV152/COVAXIN™ against hCoV-19/India/20203522 (UK-variant) and hCoV27 19/India/2020Q111 (heterologous strain). A comparable neutralization activity of the vaccinated individuals sera showed against UK-variant and the heterologous strain with similar efficiency, dispel the uncertainty of possible neutralization escape.

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Available abstract

Abstract We performed the plaque reduction neutralization test (PRNT 50 ) using sera collected from the recipients of BBV152/COVAXIN™ against hCoV-19/India/20203522 (UK-variant) and hCoV27 19/India/2020Q111 (heterologous strain). A comparable neutralization activity of the vaccinated individuals sera showed against UK-variant and the heterologous strain with similar efficiency, dispel the uncertainty of possible neutralization escape.

Key concepts: Neutralization, Heterologous, Virology, Plaque reduction neutralization test, Biology, Medicine, Virus, Genetics

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