Most rare subtypes of cutaneous lymphoma display variable CD30 expression: analysis of the German Cutaneous Lymphoma Network

coding for the IFN-induced Mx protein in skin biopsies from patients with chilblains. 4 The Mx protein sequesters viral factors required for viral replication.6 Furthermore, an IFN-induced transmembrane protein may inhibit coronavirus replication.This could explain why PCR tests are mostly negative in patients with suspected COVID-19 chilblains. 4 Battesti and Descamps reported that patients with moderately severe COVID-19 had high circulating levels of IFN-1. 4 We hypothesize that in young adults with efficient innate immune responses, the IFN-1 pathway inhibits the replication of SARS-CoV-2 and dampens the symptoms of COVID-19.In parallel, activation of the IFN-1 pathway might lead to manifestations that have been already described in interferonopathies like lupus (i.e.chilblains).The inhibition of viral replication might explain the negative RT-PCR and serological test results in the present case.To conclude, we report on a case of recurrent chilblains, the appearances of which coincided with the epidemic peaks in France and contact with a SARS-CoV-2-positive close relative.Our observation reinforces the hypothesis of a causal relationship between SARS-CoV-2 infection and chilblains.It also raises the question of whether this manifestation is likely to occur or recur during contact with SARS-CoV-2 components (e.g. during a mass vaccination campaign).