Applications of Fibrin Tissue Sealant

Abstract Tissue adhesive is a newly discovered way to replace sutures. It has been proved to be biocompatible, biodegradable, nontoxic and possesses a fast application procedure that makes surgery more effective. Tissue adhesives have been largely created from fibrin, one of the first type of naturally derived sealants, and which has widespread applications such as surgery and drug delivery. Several types of non-fibrin tissue adhesives include synthetic cyanoacrylate, aluminum-based Bio-Glue and collagen-based adhesive. Compared to non-fibrin tissue adhesives, fibrin is more biodegradable and non-toxic. This paper will mainly focus on the applications and properties of fibrin sealants and briefly introduce the non-fibrin types of tissue adhesive.