2021•Antimicrobial Agents and ChemotherapyOpen access

Boromycin Has Potent Anti-Toxoplasmaand Anti-CryptosporidiumActivity

Jaypee Abenoja, Alexis Cotto-Rosario, Roberta M. O’Connor

Abstract

Toxoplasma gondii and Cryptosporidium parvum , members of the phylum Apicomplexa, are significant pathogens of both humans and animals worldwide for which new and effective therapeutics are needed. Here, we describe the activity of the antibiotic boromycin againstToxoplasmaandCryptosporidium. Boromycin potently inhibited intracellular proliferation of both T. gondii and C. parvum at half-maximal effective concentrations (EC50) of 2.27 nM and 4.99 nM, respectively.

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Key concepts: Cryptosporidium parvum, Apicomplexa, Toxoplasma gondii, Cryptosporidium, Microbiology, Protozoa, Biology, Intracellular