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2021•Chemical CommunicationsOpen access

Fucosyltransferase-specific inhibition via next generation of fucose mimetics

Kyle C. Martin, Jacopo Tricomi, Francisco Corzana, Ana García-García, Laura Ceballos-Laita, Thomas Hicks, Serena Monaco, Jesús Angulo, Ramón Hurtado‐Guerrero, Barbara Richichi, Robert Sackstein

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Abstract

by FTIX. Our findings thus indicate that selective suppression of sLex display can be achieved, and STD-NMR studies surprisingly reveal that the mimetic does not compete with GDP-fucose at the enzymatic binding site.

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What this paper is about

by FTIX. Our findings thus indicate that selective suppression of sLex display can be achieved, and STD-NMR studies surprisingly reveal that the mimetic does not compete with GDP-fucose at the enzymatic binding site.

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OpenAlex reports 11 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

by FTIX. Our findings thus indicate that selective suppression of sLex display can be achieved, and STD-NMR studies surprisingly reveal that the mimetic does not compete with GDP-fucose at the enzymatic binding site.

Key concepts: Fucosyltransferase, Fucose, Chemistry, Fucosylation, Biochemistry, Enzyme, Galactose

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