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2021•Chemistry - A European JournalRequires access

Extended Peptide Nucleic Acid Nucleobases Based on Isoorotic Acid for the Recognition of A–U Base Pairs in Double‐Stranded RNA

Nikita Brodyagin, Aubrey L. Maryniak, Ilze Kumpiņa, John M. Talbott, Mārtiņš Katkevičs, Eriks Rozners, James A. MacKay

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Abstract

Abstract Peptide nucleic acids (PNA) with extended isoorotamide containing nucleobases (Io) were designed for binding A–U base pairs in double‐stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments revealed improved affinity for A–U using the Io scaffold in PNA. PNAs having four sequential Io extended nucleobases maintained high binding affinity.

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What this paper is about

Abstract Peptide nucleic acids (PNA) with extended isoorotamide containing nucleobases (Io) were designed for binding A–U base pairs in double‐stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments revealed improved affinity for A–U using the Io scaffold in PNA. PNAs having four sequential Io extended nucleobases maintained high binding affinity.

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Available abstract

Abstract Peptide nucleic acids (PNA) with extended isoorotamide containing nucleobases (Io) were designed for binding A–U base pairs in double‐stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments revealed improved affinity for A–U using the Io scaffold in PNA. PNAs having four sequential Io extended nucleobases maintained high binding affinity.

Key concepts: Nucleobase, Isothermal titration calorimetry, Peptide nucleic acid, Nucleic acid, RNA, Chemistry, Base pair, Nucleic acid analogue

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Extended Peptide Nucleic Acid Nucleobases Based on Isoorotic Acid for the Recognition of A–U Base Pairs in Double‐Stranded RNA — Research Paper | ScholarLens