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2020•Kidney International ReportsOpen access

Acute Acquired Fanconi Syndrome in Multiple Myeloma After Hematopoietic Stem Cell Transplantation

Janina Paula T. Sy‐Go, David Dingli, Morie Abraham Gertz, Prashant Kapoor, Francis K. Buadi, Angela A. Dispenzieri, Martha Q. Lacy, Mary E. Fidler, Nelson Leung

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Abstract

Although a rare complication, proximal tubular dysfunction of the kidneys can occur in patients with monoclonal gammopathies, including multiple myeloma (MM).1–3 Light chain proximal tubulopathy (LCPT) can occur with or without Fanconi syndrome (FS), which is the result of nonselective kidney wasting of electrolytes, uric acid, glucose, and amino acids. Clinical presentation includes hypokalemia, hypophosphatemia, proximal renal tubular acidosis (RTA), hypouricemia, normoglycemic glycosuria, and aminoaciduria.

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What this paper is about

Although a rare complication, proximal tubular dysfunction of the kidneys can occur in patients with monoclonal gammopathies, including multiple myeloma (MM).1–3 Light chain proximal tubulopathy (LCPT) can occur with or without Fanconi syndrome (FS), which is the result of nonselective kidney wasting of electrolytes, uric acid, glucose, and amino acids. Clinical presentation includes hypokalemia, hypophosphatemia, proximal renal tubular acidosis (RTA), hypouricemia, normoglycemic glycosuria, and aminoaciduria.

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OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Although a rare complication, proximal tubular dysfunction of the kidneys can occur in patients with monoclonal gammopathies, including multiple myeloma (MM).1–3 Light chain proximal tubulopathy (LCPT) can occur with or without Fanconi syndrome (FS), which is the result of nonselective kidney wasting of electrolytes, uric acid, glucose, and amino acids. Clinical presentation includes hypokalemia, hypophosphatemia, proximal renal tubular acidosis (RTA), hypouricemia, normoglycemic glycosuria, and aminoaciduria.

Key concepts: Medicine, Tubulopathy, Hypophosphatemia, Fanconi syndrome, Hypouricemia, Aminoaciduria, Glycosuria, Multiple myeloma

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