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2021•Antimicrobial Agents and ChemotherapyOpen access

Interplay among Different Fosfomycin Resistance Mechanisms in Klebsiella pneumoniae

Miriam Ortiz-Padilla, Inés Portillo-Calderón, B. de Gregorio-Iaria, Jesús Blázquez, Jesús Rodríguez‐Baño, Álvaro Pascual, José Manuel Rodríguez-Martínez, Fernando Docobo-Pérez

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Abstract

The objectives of this study were to characterize the role of the uhpT , glpT , and fosA genes in fosfomycin resistance in Klebsiella pneumoniae and evaluate the use of sodium phosphonoformate (PPF) in combination with fosfomycin. Seven clinical isolates of K. pneumoniae and the reference strain (ATCC 700721) were used, and their genomes were sequenced. Δ uhpT , Δ glpT , and Δ fosA mutants were constructed from two isolates and K. pneumoniae ATCC 700721.

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What this paper is about

The objectives of this study were to characterize the role of the uhpT , glpT , and fosA genes in fosfomycin resistance in Klebsiella pneumoniae and evaluate the use of sodium phosphonoformate (PPF) in combination with fosfomycin. Seven clinical isolates of K. pneumoniae and the reference strain (ATCC 700721) were used, and their genomes were sequenced. Δ uhpT , Δ glpT , and Δ fosA mutants were constructed from two isolates and K. pneumoniae ATCC 700721.

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Available abstract

The objectives of this study were to characterize the role of the uhpT , glpT , and fosA genes in fosfomycin resistance in Klebsiella pneumoniae and evaluate the use of sodium phosphonoformate (PPF) in combination with fosfomycin. Seven clinical isolates of K. pneumoniae and the reference strain (ATCC 700721) were used, and their genomes were sequenced. Δ uhpT , Δ glpT , and Δ fosA mutants were constructed from two isolates and K. pneumoniae ATCC 700721.

Key concepts: Fosfomycin, Klebsiella pneumoniae, Microbiology, Klebsiella infections, Klebsiella, Enterobacteriaceae, Biology, Antibiotic resistance

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