2020•PubMedRequires access

[Immune characteristics of Plasmodium reinfections in mice following chloroquine cure of primary Plasmodium infections].

Yue Wang, Xing Yao, M Y Tang, L Liu, S H Song, Zhiyong Tao, H Xia, Xianyou Chang, Qiang Fang

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Abstract

OBJECTIVE: infections with chloroquine at the peak of parasitemia. METHODS: infections. The parasitemia levels during primary infections and reinfections were measured by microscopic examinations of Giemsa-stained thin blood films, and the levels of the IgG antibody in sera and the percentages of memory T cell subsets in spleen cells were detected in mice using ELISA and flow cytometry before and after parasite reinfections, respectively. RESULTS: < 0.01). CONCLUSIONS: strains, and a higher-level resistance to re-infections with homogeneous parasite strains is found than with heterogeneous strains.

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What this paper is about

OBJECTIVE: infections with chloroquine at the peak of parasitemia. METHODS: infections. The parasitemia levels during primary infections and reinfections were measured by microscopic examinations of Giemsa-stained thin blood films, and the levels of the IgG antibody in sera and the percentages of memory T cell subsets in spleen cells were detected in mice using ELISA and flow cytometry before and after parasite reinfections, respectively. RESULTS: < 0.01). CONCLUSIONS: strains, and a higher-level resistance to re-infections with homogeneous parasite strains is found than with heterogeneous strains.

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Available abstract

OBJECTIVE: infections with chloroquine at the peak of parasitemia. METHODS: infections. The parasitemia levels during primary infections and reinfections were measured by microscopic examinations of Giemsa-stained thin blood films, and the levels of the IgG antibody in sera and the percentages of memory T cell subsets in spleen cells were detected in mice using ELISA and flow cytometry before and after parasite reinfections, respectively. RESULTS: < 0.01). CONCLUSIONS: strains, and a higher-level resistance to re-infections with homogeneous parasite strains is found than with heterogeneous strains.

Key concepts: Plasmodium yoelii, Parasitemia, Chloroquine, Plasmodium berghei, Antibody, Biology, Immune system, Malaria

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