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2020•Stem Cell ResearchOpen access

Generation of a hiPSC line ZZUNEUi012-A from a healthy female individual

Mengyu Wang, Yongjuan Ruan, Xiaoxu Tian, Yangyang Liu, Mengduan Liu, Wanrong Fu, Wenting Du, Jing Zhao, Liang Hu, Xiaowei Li, Xiaoyan Zhao, Jianzeng Dong

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Abstract

Induced pluripotent stem cells (iPSCs) have differentiation potential into different somatic cell types in vitro and are a useful tool to investigate pathomechanistic and cellular processes. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi012-A from an apparently healthy female individual using an integration-free reprogramming method. The generated hiPSC line was pluripotent and had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vitro.

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What this paper is about

Induced pluripotent stem cells (iPSCs) have differentiation potential into different somatic cell types in vitro and are a useful tool to investigate pathomechanistic and cellular processes. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi012-A from an apparently healthy female individual using an integration-free reprogramming method. The generated hiPSC line was pluripotent and had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vitro.

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Available abstract

Induced pluripotent stem cells (iPSCs) have differentiation potential into different somatic cell types in vitro and are a useful tool to investigate pathomechanistic and cellular processes. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi012-A from an apparently healthy female individual using an integration-free reprogramming method. The generated hiPSC line was pluripotent and had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vitro.

Key concepts: Reprogramming, Induced pluripotent stem cell, Biology, Germ layer, Somatic cell, Cell biology, Karyotype, In vitro

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