PRIMARY HYPERALDOSTERONISM – FACTORS OF EMERGENCE OF SECONDARY ARTERIAL HYPERTENSION

Primary hyperaldosteronism is now recognized as the most common factor of secondary hypertension. This disease is characterized by inadequately high and independent of the regulatory effects renin-angiotensin-aldosterone system by secretion of aldosterone. Among the causes of secondary arterial hypertension, primary hyperaldosteronism is from 4.6 to 13.0 %, and among patients with refractory to the medical treatment hypertension – about 20 %. It is believed that the main causes of such arterial hypertension are aldosterone-producing adenoma and bilateral hyperplasia of the adrenal glands, whose frequency is 35 and 60 % respectively. In recent years, there have been reports of genetically-identified family types of primary hyperaldosteronism, but they are not well-known to the broad public of doctors. The aim of the study – to learn the current state of the problem about the causes of secondary hypertension with primary hyperaldosteronism. Materials and Methods. The literature data for the last 5–10 years on the problem of primary hyperaldosteronism has been the material for this work to find out the current trends and views on the causative factors of the development of secondary arterial hypertension. Results and Discussion. The analysis of literature data has made it possible to determine the level of knowledge about the causes of secondary hypertension on the basis of hyperaldosteronism. It has been established that, thanks to advances in genetic research, new types of family hyperaldosteronism and aldosterone clusters of producing cells that over-produce aldosterone has been discovered, even in the absence of structural alterations in the adrenal glands. However, the problem of the influence of the results of genetic research on the choice of treatment method and treatment of patients with primary hyperaldosteronism remain questions of discourse and unexplored problems.