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2020•Indian Journal of Child HealthOpen access

Devic’s disease – A case report

Kapil Bainade, Veeranna Kotrashetti, Vijay Baburao Sonawane, Amit Vatkar, Saili Bunde

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Abstract

Devic disease (Neuromyelitis Optica – [NMO]) is a severe inflammatory demyelinating condition that targets astrocytes in the optic nerves and spinal cord. It is characterized by optic neuritis and transverse myelitis. The disease is very rare with an incidence of 0.05–0.4% and female predominance. NMO is easily misdiagnosed with multiple sclerosis (MS) as characterized by relapses. The best predictor to differentiate NMO from MS is the presence of serum antibody to Aquaporin-4 called as NMO-immunoglobulin G.

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What this paper is about

Devic disease (Neuromyelitis Optica – [NMO]) is a severe inflammatory demyelinating condition that targets astrocytes in the optic nerves and spinal cord. It is characterized by optic neuritis and transverse myelitis. The disease is very rare with an incidence of 0.05–0.4% and female predominance. NMO is easily misdiagnosed with multiple sclerosis (MS) as characterized by relapses. The best predictor to differentiate NMO from MS is the presence of serum antibody to Aquaporin-4 called as NMO-immunoglobulin G.

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Available abstract

Devic disease (Neuromyelitis Optica – [NMO]) is a severe inflammatory demyelinating condition that targets astrocytes in the optic nerves and spinal cord. It is characterized by optic neuritis and transverse myelitis. The disease is very rare with an incidence of 0.05–0.4% and female predominance. NMO is easily misdiagnosed with multiple sclerosis (MS) as characterized by relapses. The best predictor to differentiate NMO from MS is the presence of serum antibody to Aquaporin-4 called as NMO-immunoglobulin G.

Key concepts: Neuromyelitis optica, Transverse myelitis, Optic neuritis, Multiple sclerosis, Myelitis, Medicine, Spinal cord, Demyelinating disease

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