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2020•Journal of Clinical & Experimental Dermatology ResearchRequires access

Epidermolysis Bullosa Acquisita: A Case Report

Lafuente Cevallos Lizeth Veronica, Urena Lopez Valeria Alex, Ra ', Lascano Gallegos Nathalie, Palacios Alvarez Santiago Alberto

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Abstract

Epidermolysis Bullosa Acquisita (EBA) is a chronic autoimmune subepidermal blistering disease developed after damage to type VII collagen by autoantibodies. Type VII collagen is the major component of anchoring fibrils in the sub-lamina densa hemidesmosomes of the skin and squamous mucosas. The worldwide incidence is estimated between 0.2-0.5/million inhabitants per year. Two major clinical variants have been described: the mechanobullous, and the inflammatory EBA.

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What this paper is about

Epidermolysis Bullosa Acquisita (EBA) is a chronic autoimmune subepidermal blistering disease developed after damage to type VII collagen by autoantibodies. Type VII collagen is the major component of anchoring fibrils in the sub-lamina densa hemidesmosomes of the skin and squamous mucosas. The worldwide incidence is estimated between 0.2-0.5/million inhabitants per year. Two major clinical variants have been described: the mechanobullous, and the inflammatory EBA.

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Available abstract

Epidermolysis Bullosa Acquisita (EBA) is a chronic autoimmune subepidermal blistering disease developed after damage to type VII collagen by autoantibodies. Type VII collagen is the major component of anchoring fibrils in the sub-lamina densa hemidesmosomes of the skin and squamous mucosas. The worldwide incidence is estimated between 0.2-0.5/million inhabitants per year. Two major clinical variants have been described: the mechanobullous, and the inflammatory EBA.

Key concepts: Epidermolysis bullosa acquisita, Anchoring fibrils, Hemidesmosome, Medicine, Autoantibody, Dermatology, Epidermolysis bullosa, Pathology

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