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2020•Chemistry & BiodiversityRequires access

Two New Limonoids from the Fruits of Melia azedarach (Meliaceae)

Wenqi Wang, Zhen‐Zhen Xia, Shaohua Yu, Zhenhua Tian, Bin Yan, Haiqiang Jiang, Honglei Zhou

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Abstract

Abstract Two new limonoids, trichilinin M (1) and ohchinin benzoate (2), along with two known limonoids, 12‐hydroxyamoorastatone (3) and mesendanin H (4), were isolated from the fruits of Melia azedarach Linn. The structures of new limonoids were determined by analyses of HR‐ESI‐MS, 1D and 2D NMR (HSQC, HMBC and NOESY) data. All compounds were evaluated against human pancreatic cancer PANC1 cells and the results showed that compounds 3–4 exhibited substantial cytotoxic activity (3: IC50=4.55 μM; 4: IC50=7.54 μM), and compounds 1–2 exhibited moderate cytotoxicity (1: IC50=27.06 μM; 2: IC50=21.17 μM).

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What this paper is about

Abstract Two new limonoids, trichilinin M (1) and ohchinin benzoate (2), along with two known limonoids, 12‐hydroxyamoorastatone (3) and mesendanin H (4), were isolated from the fruits of Melia azedarach Linn. The structures of new limonoids were determined by analyses of HR‐ESI‐MS, 1D and 2D NMR (HSQC, HMBC and NOESY) data. All compounds were evaluated against human pancreatic cancer PANC1 cells and the results showed that compounds 3–4 exhibited substantial cytotoxic activity (3: IC50=4.55 μM; 4: IC50=7.54 μM), and compounds 1–2 exhibited moderate cytotoxicity (1: IC50=27.06 μM; 2: IC50=21.17 μM).

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Available abstract

Abstract Two new limonoids, trichilinin M (1) and ohchinin benzoate (2), along with two known limonoids, 12‐hydroxyamoorastatone (3) and mesendanin H (4), were isolated from the fruits of Melia azedarach Linn. The structures of new limonoids were determined by analyses of HR‐ESI‐MS, 1D and 2D NMR (HSQC, HMBC and NOESY) data. All compounds were evaluated against human pancreatic cancer PANC1 cells and the results showed that compounds 3–4 exhibited substantial cytotoxic activity (3: IC50=4.55 μM; 4: IC50=7.54 μM), and compounds 1–2 exhibited moderate cytotoxicity (1: IC50=27.06 μM; 2: IC50=21.17 μM).

Key concepts: Melia azedarach, Meliaceae, Limonoid, Chemistry, Cytotoxicity, Two-dimensional nuclear magnetic resonance spectroscopy, Stereochemistry, Traditional medicine

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