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2021•StatPearlsRequires access

Minimal Change Disease

Glenda Zamora, Anthony L. Pearson-Shaver

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Abstract

Minimal change disease (MCD) is one of the most common causes of idiopathic nephrotic syndrome in children. It accounts for 70% to 90% of children that present with nephrotic syndrome who are older than one year old as opposed to 10-15% of adults who present with nephrotic syndrome. Minimal change disease is distinctive for proteinuria that results in edema and intravascular volume depletion, with good response to steroids. Minimal Change Disease has been labeled “minimal change lesion,” “nil disease,” “lipoid nephrosis (a description of lipid droplets in urine seen on light microscopy). Minimal change disease has a particularly good prognosis in pediatric patients.

About this research paper

What this paper is about

Minimal change disease (MCD) is one of the most common causes of idiopathic nephrotic syndrome in children. It accounts for 70% to 90% of children that present with nephrotic syndrome who are older than one year old as opposed to 10-15% of adults who present with nephrotic syndrome. Minimal change disease is distinctive for proteinuria that results in edema and intravascular volume depletion, with good response to steroids. Minimal Change Disease has been labeled “minimal change lesion,” “nil disease,” “lipoid nephrosis (a description of lipid droplets in urine seen on light microscopy). Minimal change disease has a particularly good prognosis in pediatric patients.

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Available abstract

Minimal change disease (MCD) is one of the most common causes of idiopathic nephrotic syndrome in children. It accounts for 70% to 90% of children that present with nephrotic syndrome who are older than one year old as opposed to 10-15% of adults who present with nephrotic syndrome. Minimal change disease is distinctive for proteinuria that results in edema and intravascular volume depletion, with good response to steroids. Minimal Change Disease has been labeled “minimal change lesion,” “nil disease,” “lipoid nephrosis (a description of lipid droplets in urine seen on light microscopy). Minimal change disease has a particularly good prognosis in pediatric patients.

Key concepts: Minimal change disease, Nephrosis, Nephrotic syndrome, Medicine, Proteinuria, Edema, Disease, Lesion

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