2020•Natural Product ResearchRequires access
A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities
Jie Feng, Danyang Zhao, Qiannan Xu, Xiangzhong Liu, Mi Ζhou, Xiansheng Ye, Ting Lin, Guanghui Wang, Cuiling Sun, Rong Ding, Wenjing Tian, Haifeng Chen
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Abstract
A undescribed phenolic glycoside, trochinenol A (1), was isolated from the flowers of Trollius chinensis Bunge and the structure was identified by spectroscopic methods. Its anti-inflammatory and antibacterial effects were investigated by broth microdilution and NF-κB reporter gene assays. Consequently, compound 1 exhibited an appreciable effect against Staphylococcus aureus with the MIC value of 6.25 µg/mL. Besides, it showed moderate effect against TNFα-induced activation of NF-κB pathway.