A randomized controlled trial evaluating inhalation and intravenous anesthesia for laparoscopic cholecystectomy

ABSTRACT Background: Propofol and isoflurane have been used as anesthetic drug. Objective: For the purpose of this research, we compared total intravenous (IV) anesthesia (TIVA) with propofol and inhalational anesthesia of isoflurane on hhemodynamic parameters. Method: This study is a randomized clinical trial, carried out on patients aged 20–40 years; they were randomly divided into two groups. The anesthetics drug administered in both groups were similar. This study comprises of 92 patients undergoing LC. The patients were divided into two groups, forty-six (46) patients received inhaled anesthesia with isoflurane (Group I), and the other forty-six (46) in propofol group (Group P). Hemodynamic variables and depth of anesthesia at various distances were measured and recorded. Result: In this study, the difference in depth of anesthesia between the two groups over a period of time was statistically significant. Changes in hemodynamic parameters such as HR, SBP and DBP between the two groups was statistically significant over time. Bispectral index in the group receiving isoflurane was statistically lower than those in propofol-based anesthetic treated group (p = 0.051). Conclusion: Propofol and isoflurane are appropriate agent used as a relaxant after general anesthesia for LC. Thus, propofol unlike isoflurane provide less hemodynamic changes, and presented a greater hemodynamic stability. This clinical trial was carried out in Iran at the center of clinical trial registered with a special registration code: IRCT2015092716516N2. Highlights