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Mucosa-associated Lymphoma Tissue

Sanjana Mullangi, Manidhar Reddy Lekkala

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Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of the marginal zone lymphoma (MZL), which is non-Hodgkin lymphoma. It is also called extranodal marginal zone lymphoma (EMZL). It is frequently noted in the stomach but virtually can involve any mucosal site like the salivary gland, ocular adnexa, lung, and elsewhere. EMZL is clinically distinct from the other types of MZL, the splenic marginal zone lymphoma (SMZL), and the nodal marginal zone lymphoma (NMZL) with specific diagnostic criteria, clinical behavior, different genetic features, and therapeutic implications. Other commonly used terminologies for MALT lymphoma are “MALToma,” “MALT-type lymphoma,” and “pseudo-lymphoma.” In this review, we interchangeably use MALT lymphoma with EMZL.

About this research paper

What this paper is about

Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of the marginal zone lymphoma (MZL), which is non-Hodgkin lymphoma. It is also called extranodal marginal zone lymphoma (EMZL). It is frequently noted in the stomach but virtually can involve any mucosal site like the salivary gland, ocular adnexa, lung, and elsewhere. EMZL is clinically distinct from the other types of MZL, the splenic marginal zone lymphoma (SMZL), and the nodal marginal zone lymphoma (NMZL) with specific diagnostic criteria, clinical behavior, different genetic features, and therapeutic implications. Other commonly used terminologies for MALT lymphoma are “MALToma,” “MALT-type lymphoma,” and “pseudo-lymphoma.” In this review, we interchangeably use MALT lymphoma with EMZL.

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Available abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of the marginal zone lymphoma (MZL), which is non-Hodgkin lymphoma. It is also called extranodal marginal zone lymphoma (EMZL). It is frequently noted in the stomach but virtually can involve any mucosal site like the salivary gland, ocular adnexa, lung, and elsewhere. EMZL is clinically distinct from the other types of MZL, the splenic marginal zone lymphoma (SMZL), and the nodal marginal zone lymphoma (NMZL) with specific diagnostic criteria, clinical behavior, different genetic features, and therapeutic implications. Other commonly used terminologies for MALT lymphoma are “MALToma,” “MALT-type lymphoma,” and “pseudo-lymphoma.” In this review, we interchangeably use MALT lymphoma with EMZL.

Key concepts: Marginal zone, Lymphoma, MALT lymphoma, Mucosa-associated lymphoid tissue, Pathology, Medicine, Marginal zone B-cell lymphoma, Lymphatic system

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