Comparison of Salivary and Serum C Reactive Protein Levels in Periodontitis and Healthy Patients using ELISA - A Clinico Pathological Study

Background: Periodontitis is one of the most common chronic inflammatory diseases in the world. C-reactive protein (CRP) is important due to its crucial role in atherosclerosis as a marker. This study evaluates both salivary and serum CRP levels, Gingival Index, Plaque Index, Bleeding Index, and probing pocket depth. Methodology: A total of 150 participants were enrolled, out of which 50 were healthy, i.e., did not have periodontitis, 50 patients were suffering from chronic periodontitis previously called adult periodontitis, and 50 patients were suffering from aggressive periodontitis with features of rapid attachment loss and bone destruction. All these patients were divided into three groups, and salivary as well as serum samples were collected from each group which were analyzed using enzyme-linked immunosorbent assay. Results: The results showed that both salivary and serum CRP levels were highest in aggressive periodontitis patients followed by chronic periodontitis patients and least in healthy individuals. Conclusion: Both salivary and serum CRP are effective markers in evaluating the severity of periodontal disease.