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Bloedingsrisico bij gebruik van fluoxetine (Prozac) of fluvoxamine (Fevarin)

Jan Paul Ottervanger, Patricia M. L. A. van den Bemt, Gabriella Koning, Bruno H. Stricker

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Abstract

Fluoxetine (Prozac) and fluvoxamine (Fevarin) are nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitors prescribed for the treatment of depression. Since these drugs block serotonin reuptake in platelets also, they might under certain conditions lead to clinically significant platelet dysfunction. Four patients are described who developed bleeding during treatment with either fluoxetine or fluvoxamine.

About this research paper

What this paper is about

Fluoxetine (Prozac) and fluvoxamine (Fevarin) are nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitors prescribed for the treatment of depression. Since these drugs block serotonin reuptake in platelets also, they might under certain conditions lead to clinically significant platelet dysfunction. Four patients are described who developed bleeding during treatment with either fluoxetine or fluvoxamine.

Why it matters

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Method / approach

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Main findings

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Available abstract

Fluoxetine (Prozac) and fluvoxamine (Fevarin) are nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitors prescribed for the treatment of depression. Since these drugs block serotonin reuptake in platelets also, they might under certain conditions lead to clinically significant platelet dysfunction. Four patients are described who developed bleeding during treatment with either fluoxetine or fluvoxamine.

Key concepts: Fluvoxamine, Fluoxetine, Medicine, Reuptake inhibitor, Serotonin reuptake inhibitor, Serotonin, Pharmacology, Paroxetine

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Bloedingsrisico bij gebruik van fluoxetine (Prozac) of fluvoxamine (Fevarin) — Research Paper | ScholarLens