1976•The Japanese Journal of PharmacologyOpen access
Alteration of enzyme activities related to neurotransmitter biosynthesis in superior cervical ganglion and adrenal gland following ganglionic blockade with ganglion blocking agents
Makoto Muramatsu, Kazuo Nakagawa, Kinya Kuriyama
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Abstract
Alteration of enzyme activities -relac.ed to neurot:rannd.1:terbiosynthesia in the aupe-rio-r cervical.ganglion (SCG) and adrenal gland oI the -rat was examined following the administration of ganglion blocking agents.By transsecting p-reganglionic nerve trunks of the SCG, choline acetylt-r8J\sfe-rase (ChAc) and adenylate cyclase (A-c) activities of tha SCG showed a significant dec-reaae, whereas the activity of t}'l:osine hyd-roxylase {'l'-OB), was oot significantly altered.On the otbe.rband, the continuous administration of hexamethonium {C,; 50mg/kg, twice daily, every 12 h-r) induced a t-ransient but significant inc-rease of T-011 and A-c activities in the SCG at: 3-S days
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