Comparison of the Mydriatic Effects of Mydrin-P and Compound Tropicamide in the Screening of Retinopathy of Prematurity

Purpose: To observe and compare the effects of pupil dilation between Mydrin-P and compound tropicamide in the screening of retinopathy of prematurity.Methods:.The right eyes of premature infants received Mydrin-P eye drops as the treatment group, whereas the left eyes were administered with compound tropicamide as the control group..The eye drops were delivered every 5 min for three times..The pupil size was observed and recorded at 10,.15,and 20 min after administering mydriasis.Results:.The mean pupil diameter did not significantly differ between the treatment and control groups at 10.(6.24 ±0.72 mm vs. 6.24±0.68 mm, t=0.00, P=1.00), 15(6.83±0.55 mm vs. 6.78±0.54 mm, t=1.75, P=0.083) or 20 min(7.22±0.40 mm vs. 7.15±0.50 mm, t=1.62, P=0.109), respectively. However, the mean pupil size at any two time points significantly differed in both groups(all P<0.001).Conclusion: Both Mydrin-P and compound tropicamide exert similar clinical efficacy in the screening of retinopathy of prematurity..The most appropriate time for screening was at 20 min after mydriasis.