ANTIBIOTICS COMBINATION EFFECTS OF TYLOSIN AND ENROFLOXACIN ON LIVER AND RENAL FUNCTIONS OF BROILER

The combination of tylosin and enrofloxacin antibiotics is a new drug that is intended as a medicated feed in the world of poultry. Therefore before being marketed in the community this drug needs to be tested first. The purpose of this study was to find out the effects of tylosin and enrofloxacin as combination antibiotic on liver and renal functions of broiler chickens.Fourty (40) broilers maintained in the animal cages from Day Old Chick (DOC) and has given feed and water ad libitum. Broilers were divided into four groups each containing 10 chickens. Group I was those who were treated with combination of tylosin and enrofloxacin antibiotics 0,5 gram in 2 liters of drinking water, group II was treated at dose of 1 grams in 2 liters of drinking water, group III was treated at dose of 2 gram in 2 liters of drinking water, while group IV as a control without antibiotics treatment. The treatment of combination antibiotics was carried out 7 day. Blood samples were collected at the 30th day. Blood samples were used for examination of Alanine Transaminase (ALT) and creatinine concentration. Liver and renal. sample for histological examination.The results of the statistical analysis showed that combination antibiotics of tylosin and enrofloxacin had no significant effect on ALT and creatinine concentration of broiler chickens. The highest concentrations of ALT and creatinine were Group II (20,333±18,768 U/L) and group III (0.4 ± 0 mg/dL), respectively. Histological observation of liver and renal organs showed that all groups were normal and there is no pathology. Based on this study can be concluded that the combination of tylosin and enrofloxacin antibiotics for 7 days did not affect the function of liver and renal broiler. Key words : tylosin, enrofloxacin, ALT, creatinine, broiler.