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2020•Molecular Therapy — Nucleic AcidsOpen access

ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis

Hao Yu, Xiao Feng Yang, Jinyuan Tang, Shuhui Si, Zijian Zhou, Jiancheng Lu, Jie Han, Baorui Yuan, Qikai Wu, Qiang Lü, Haiwei Yang

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Abstract

, whereas ALKBH5 overexpression led to the opposite results. Finally, ALKBH5 inhibited the progression and sensitized bladder cancer cells to cisplatin through a casein kinase 2 (CK2)α-mediated glycolysis pathway in an m6A-dependent manner. Taken together, these findings might provide fresh insights into bladder cancer therapy.

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, whereas ALKBH5 overexpression led to the opposite results. Finally, ALKBH5 inhibited the progression and sensitized bladder cancer cells to cisplatin through a casein kinase 2 (CK2)α-mediated glycolysis pathway in an m6A-dependent manner. Taken together, these findings might provide fresh insights into bladder cancer therapy.

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OpenAlex reports 242 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

, whereas ALKBH5 overexpression led to the opposite results. Finally, ALKBH5 inhibited the progression and sensitized bladder cancer cells to cisplatin through a casein kinase 2 (CK2)α-mediated glycolysis pathway in an m6A-dependent manner. Taken together, these findings might provide fresh insights into bladder cancer therapy.

Key concepts: Demethylase, AlkB, Biology, Bladder cancer, Gene knockdown, Cancer research, RNA, Cancer

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ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis — Research Paper | ScholarLens