2020•Ocular Immunology and InflammationOpen access
Clinical Relevance of Subcentimetric Lymph Node Biopsy in the Diagnosis of Ocular Sarcoidosis
Elena Bolletta, Valentina Mastrofilippo, Alessandro Invernizzi, Raffaella Aldigeri, Lucia Spaggiari, Giulia Besutti, Roberto Borrelli, Filippo Lococo, Tommaso Ricchetti, Cristian Rapicetta, Alberto Cavazza, Giovanni Musci, Luca De Simone, Fabrizio Gozzi, Carlo Salvarani, Nicolò Pipitone, Massimiliano Paci, Luca Cimino
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Abstract
PURPOSE: To evaluate the clinical relevance of subcentimetric lymph node biopsy via mediastinoscopy in patients with presumed ocular sarcoidosis (OS). METHODS: Retrospective study of consecutive patients who underwent biopsy via mediastinoscopy for suspected OS. The biopsy outcomes and clinical features of patients with subcentimetric nodes and of those with lymph nodes >1 cm were compared. RESULTS: A total of 67 patients with presumed OS were included. Forty-two patients (63%) had lymph nodes ≥1 cm in diameter, while 25(37%) showed subcentimetric lymph nodes. Biopsy was consistent with sarcoidosis in 83% of patients with lymph nodes ≥1 cm and in 76% of patients with subcentimetric lymph nodes (p = .60). Patients with OS who had subcentimetric lymph nodes had less lymphopenia (p = .01), lower lysozyme values (p = .03) and a longer diagnostic delay compared to those with larger lymph nodes. CONCLUSIONS: The biopsy of subcentimetric lymph nodes via mediastinoscopy may provide a histological diagnosis and reduce diagnostic delay.