Epoxyeicosanoids Role in Hypertension

Epoxyeicosatrienoic acids (EETs) are 20 carbon epoxy fatty acids also known as epoxyeicosanoids. EETs are generated from arachidonic acid by cytochrome (CYP) P450 epoxygenases. Epoxyeicosatrienoic acids (EETs) have cardiovascular and renal actions and these actions can be regulated by soluble Epoxide Hydrolase (SEH) that degrades and inactivates EETs have reduced or no biological activity. Epoxyeicosanoids have natriuretic, vasodilator and anti-inflammatory activities lower blood pressure and also decrease the cardiovascular and renal disease progression. EETs are produced and have activities in endothelial kidney, heart, cells and other organs that impact blood pressure regulation. Blood pressure regulating EET actions include vasodilation, increasing sodium excretion, and decreasing inflammation. CYP2C epoxygenase enzyme gene variants demonstrate increased risk for essential hypertension and reduced EET generation.