2017StatPearlsRequires access

Acute Kidney Injury

Abhinav Goyal, Parnaz Daneshpajouhnejad, Muhammad F. Hashmi, Khalid Bashir

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Abstract

Acute kidney injury (AKI), previously called acute renal failure (ARF), denotes a sudden and often reversible reduction in the kidney function, as measured by glomerular filtration rate (GFR). Although, immediately after a renal insult, blood urea nitrogen (BUN) or creatinine levels may be within the normal range and the only sign of the acute kidney injury may be a decline in urine output. AKI can lead to the accumulation of water, sodium, and other metabolic products. It can also result in a number of electrolyte disturbances. It is a very common condition, especially among hospitalized patients. It can be seen in up to 7% of hospital admissions and 30% ICU admissions. There is no clear definition of AKI; however, several different criteria have been used in research studies such as RIFLE, AKIN (Acute Kidney Injury Network) and KDIGO (Kidney Disease: Improving Global Outcomes) criteria. Among these, KDIGO is the most recent and most commonly used tool. According to KDIGO, AKI is the presence of any of the following:

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What this paper is about

Acute kidney injury (AKI), previously called acute renal failure (ARF), denotes a sudden and often reversible reduction in the kidney function, as measured by glomerular filtration rate (GFR). Although, immediately after a renal insult, blood urea nitrogen (BUN) or creatinine levels may be within the normal range and the only sign of the acute kidney injury may be a decline in urine output. AKI can lead to the accumulation of water, sodium, and other metabolic products. It can also result in a number of electrolyte disturbances. It is a very common condition, especially among hospitalized patients. It can be seen in up to 7% of hospital admissions and 30% ICU admissions. There is no clear definition of AKI; however, several different criteria have been used in research studies such as RIFLE, AKIN (Acute Kidney Injury Network) and KDIGO (Kidney Disease: Improving Global Outcomes) criteria. Among these, KDIGO is the most recent and most commonly used tool. According to KDIGO, AKI is the presence of any of the following:

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Available abstract

Acute kidney injury (AKI), previously called acute renal failure (ARF), denotes a sudden and often reversible reduction in the kidney function, as measured by glomerular filtration rate (GFR). Although, immediately after a renal insult, blood urea nitrogen (BUN) or creatinine levels may be within the normal range and the only sign of the acute kidney injury may be a decline in urine output. AKI can lead to the accumulation of water, sodium, and other metabolic products. It can also result in a number of electrolyte disturbances. It is a very common condition, especially among hospitalized patients. It can be seen in up to 7% of hospital admissions and 30% ICU admissions. There is no clear definition of AKI; however, several different criteria have been used in research studies such as RIFLE, AKIN (Acute Kidney Injury Network) and KDIGO (Kidney Disease: Improving Global Outcomes) criteria. Among these, KDIGO is the most recent and most commonly used tool. According to KDIGO, AKI is the presence of any of the following:

Key concepts: Acute kidney injury, Renal function, Rifle, Medicine, Creatinine, Kidney disease, Kidney, Blood urea nitrogen

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