2020•PubMedRequires access

[A Study on the Role and Mechanism of Fenofibrate in Mice Renal Fibrosis Induced by Unilateral Ureteral Obstruction].

Shanshan Xu, Sha Li, Xiaxia Zhang, Jun-Zhi Qi, Guiying Li

Abstract

OBJECTIVE: To investigate the role and mechanism of fenofibrate in renal fibrosis induced by unilateral ureteral obstruction in mice, and to provide a potential therapeutic target for renal fibrosis. METHODS: . RESULTS: <0.05). CONCLUSION: Fenofibrate reduced mice renal fibrosis caused by unilateral ureteral obstruction and its mechanism may be relate to its regulation effect on the expressions of renal tissue fibrosis related genes.

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Key concepts: Sirius Red, Hydroxyproline, Medicine, Kidney, Fenofibrate, Creatinine, Saline, Blood urea nitrogen