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2020•mBioOpen access

Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis

Kangmin Hua, Xiangyang Liu, Yuchun Zhao, Yaojie Gao, Lifeng Pan, Haoran Zhang, Zixin Deng, Ming Sen Jiang

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Abstract

Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KS α ), chain length factor (KS β ), and acyl carrier protein (ACP), are utilized to elongate the polyketide chain through a repetitive condensation reaction. During each condensation, the biosynthesis intermediates are covalently attached to KS α or ACP via a thioester bond and are then cleaved to release an elongated polyketide chain for successive postmodification.

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What this paper is about

Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KS α ), chain length factor (KS β ), and acyl carrier protein (ACP), are utilized to elongate the polyketide chain through a repetitive condensation reaction. During each condensation, the biosynthesis intermediates are covalently attached to KS α or ACP via a thioester bond and are then cleaved to release an elongated polyketide chain for successive postmodification.

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Available abstract

Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KS α ), chain length factor (KS β ), and acyl carrier protein (ACP), are utilized to elongate the polyketide chain through a repetitive condensation reaction. During each condensation, the biosynthesis intermediates are covalently attached to KS α or ACP via a thioester bond and are then cleaved to release an elongated polyketide chain for successive postmodification.

Key concepts: Polyketide, Acyl carrier protein, Biosynthesis, Thioester, Polyketide synthase, Thioesterase, Chemistry, Enzyme

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