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2020•Antimicrobial Agents and ChemotherapyOpen access

Multicentric Analysis of the Species Distribution and Antifungal Susceptibility of Cryptic Isolates from Aspergillus Section Fumigati

Sébastien Imbert, Anne‐Cécile Normand, Sophie Cassaing, Frédéric Gabriel, Lena Hagelskjær Kristensen, Christine Bonnal, Laurence Lachaud, Damien Costa, J. Guitard, Lilia Hasseine, Martine Palous, Martine Piarroux, Marijke Hendrickx, Renaud Piarroux, Arnaud Fekkar

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Abstract

The antifungal susceptibility of Aspergillus cryptic species is poorly known. We assessed 51 isolates, belonging to seven Fumigati cryptic species, by the EUCAST reference method and the concentration gradient strip (CGS) method. Species-specific patterns were observed, with high MICs for azole drugs, except for Aspergillus hiratsukae and Aspergillus tsurutae , and high MICs for amphotericin B for Aspergillus lentulus and Aspergillus udagawae .

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What this paper is about

The antifungal susceptibility of Aspergillus cryptic species is poorly known. We assessed 51 isolates, belonging to seven Fumigati cryptic species, by the EUCAST reference method and the concentration gradient strip (CGS) method. Species-specific patterns were observed, with high MICs for azole drugs, except for Aspergillus hiratsukae and Aspergillus tsurutae , and high MICs for amphotericin B for Aspergillus lentulus and Aspergillus udagawae .

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Available abstract

The antifungal susceptibility of Aspergillus cryptic species is poorly known. We assessed 51 isolates, belonging to seven Fumigati cryptic species, by the EUCAST reference method and the concentration gradient strip (CGS) method. Species-specific patterns were observed, with high MICs for azole drugs, except for Aspergillus hiratsukae and Aspergillus tsurutae , and high MICs for amphotericin B for Aspergillus lentulus and Aspergillus udagawae .

Key concepts: Antifungal, Aspergillus, Biology, Fungi imperfecti, Species complex, Microbiology, Section (typography), Genetics

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