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2020•Frontiers in EndocrinologyOpen access

Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

Didier Dewailly, Anne‐Laure Barbotin, Agathe Dumont, Sophie Catteau-Jonard, Geoffroy Robin

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Abstract

Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.

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What this paper is about

Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.

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OpenAlex reports 101 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.

Key concepts: Anti-Müllerian hormone, Polycystic ovary, Folliculogenesis, Pathogenesis, Medicine, Internal medicine, Endocrinology, Hormone

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