Evaluation of CD68 in Oral Squamous Cell Carcinoma and their Relation with Clinicopathological Parameters –An Immunohistochemical Study

Macrophages are important cells for the innate immunity. Circulating monocytes are attracted to tissues by chemotactic factors and become macrophages under the influence of their microenvironment. Several studies have shown that macrophages are important to the prognosis of patients with different types of cancer. The aim of this study was to evaluate the expression of CD68 in OSCC patients and to investigate the possible relationship of macrophages using CD68 in various histopathological grades, stages and other clinical parameters of OSCC. preoperative diagnosed specimens (n=30)were processed for immunohistochemistry to detect CD68 positive cells. Expression of macrophages was semiquantitatively analyzed. Immunohistochemical study show expression of CD68 in all specimens. A significant correlation between CD68 infiltration and gender of patients was found,where it high in females than males. Other clinicopathological findings of OSCC show non-significant correlation. Immunohistochemical expression of CD68 were observed in all studying samples of oral squamous cell carcinoma. however, statistically non-significant correlation was found between the mean expression level of these infiltrates macrophages with clinicopathological findings of OSCC expect with Gender.