2020•Bioorganic & Medicinal Chemistry LettersOpen access

Discovery of ONO-8590580: A novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders

Arwel Lewis, Alan Beresford, Mark S. Chambers, Gary S. Clark, D.C. Hartley, Kim L. Hirst, Masato Higashino, S. Kawahadara, Miki Nakanishi, Tetsuji Saito, Akira Imagawa, Hiromu Habashita, Scott A. Maidment, Angus M. MacLeod, Andrew P. Owens, A. David Rae, Craig Rouse, Graham N. Wishart

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Key concepts: Allosteric regulation, GABAA receptor, Chemistry, Allosteric modulator, Neuroactive steroid, Functional selectivity, Pharmacology, Receptor