2009•Journal of Pharmaceutical and Biomedical SciencesRequires access
Optimization of Somatic Cell Nuclear Transfer in Pigs
Defu Zhang, Jianjun Dai, Wu CaiFeng, Huali Wu, Dong Liu, Xuejin Chen, Yin Chen, Kai Wang
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Abstract
It has been almost eight years since the live piglets produced by somatic cell nuclear transfer (SCNT) technology was first reported. Although it is more difficult and low efficiency (1%~2%) compared with embryonic cell nuclear (ECNT) technology, the cloning pigs with SCNT technology has been gotten further studied, and some progress has been taken in its mechanism and approaches. In this article, the key technology and difficulties of SCNT in cloning pigs, including applications and approach of increasing the efficiency of SCNT was mainly reviewed.