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2020•PubMedOpen access

[Effects of stachyine on apoptosis in an Aβ25-35-induced PC12 cell model of Alzheimer's disease].

Liangchao Qu, Jiajia Huang, Mingda Fan, Yuchen Hao, Jinxiu Yan

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Abstract

OBJECTIVE: -induced PC12 cells mimicking Alzheimer's disease and explore the mechanisms. METHODS: to establish a cell model of Alzheimer's disease, and the changes in cell viability and cell cycle in response to STA treatment were assessed using MTT assay and flow cytometry, respectively. RT-PCR and Western blotting were used to detect the relevant gene or protein expressions in the treated cells. RESULTS: < 0.05). CONCLUSIONS: possibly by regulating RPS8 and EED expression to promote the expressions of Bcl-2 and p53.

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What this paper is about

OBJECTIVE: -induced PC12 cells mimicking Alzheimer's disease and explore the mechanisms. METHODS: to establish a cell model of Alzheimer's disease, and the changes in cell viability and cell cycle in response to STA treatment were assessed using MTT assay and flow cytometry, respectively. RT-PCR and Western blotting were used to detect the relevant gene or protein expressions in the treated cells. RESULTS: < 0.05). CONCLUSIONS: possibly by regulating RPS8 and EED expression to promote the expressions of Bcl-2 and p53.

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Available abstract

OBJECTIVE: -induced PC12 cells mimicking Alzheimer's disease and explore the mechanisms. METHODS: to establish a cell model of Alzheimer's disease, and the changes in cell viability and cell cycle in response to STA treatment were assessed using MTT assay and flow cytometry, respectively. RT-PCR and Western blotting were used to detect the relevant gene or protein expressions in the treated cells. RESULTS: < 0.05). CONCLUSIONS: possibly by regulating RPS8 and EED expression to promote the expressions of Bcl-2 and p53.

Key concepts: Apoptosis, Flow cytometry, Viability assay, Cell cycle, Molecular biology, Blot, Gene, Cell

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[Effects of stachyine on apoptosis in an Aβ25-35-induced PC12 cell model of Alzheimer's disease]. — Research Paper | ScholarLens