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2020•Journal of Clinical MicrobiologyOpen access

Susceptibility of Clinical Isolates of Escherichia coli to Fosfomycin as Measured by Four In Vitro Testing Methods

James A. Karlowsky, Philippe Lagacé‐Wiens, Nancy M. Laing, Melanie Baxter, Heather J. Adam, George G. Zhanel

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Abstract

Clinical isolates of Escherichia coli ( n = 554) were tested against fosfomycin using agar dilution, disk diffusion, and Etest. Agar dilution (reference method) identified few isolates with fosfomycin MICs of 64 ( n = 3), 128 ( n = 4), and ≥256 μg/ml ( n = 2). Applying CLSI (M100, 2020) and EUCAST (v. 10.0, 2020) breakpoints, 98.9% and 98.4% (agar dilution), 99.

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What this paper is about

Clinical isolates of Escherichia coli ( n = 554) were tested against fosfomycin using agar dilution, disk diffusion, and Etest. Agar dilution (reference method) identified few isolates with fosfomycin MICs of 64 ( n = 3), 128 ( n = 4), and ≥256 μg/ml ( n = 2). Applying CLSI (M100, 2020) and EUCAST (v. 10.0, 2020) breakpoints, 98.9% and 98.4% (agar dilution), 99.

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Available abstract

Clinical isolates of Escherichia coli ( n = 554) were tested against fosfomycin using agar dilution, disk diffusion, and Etest. Agar dilution (reference method) identified few isolates with fosfomycin MICs of 64 ( n = 3), 128 ( n = 4), and ≥256 μg/ml ( n = 2). Applying CLSI (M100, 2020) and EUCAST (v. 10.0, 2020) breakpoints, 98.9% and 98.4% (agar dilution), 99.

Key concepts: Fosfomycin, Agar dilution, Etest, Agar, Microbiology, Agar Dilution Method, Escherichia coli, Biology

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