2020•AgingOpen access

circKIF4A sponges miR-127 to promote ovarian cancer progression

Shunliang Sheng, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Yanlin Cai, Jiayu Zhu

Abstract

. The results revealed that circKIF4A was highly expressed in ovarian cancer tissues. Knockdown of circKIF4A suppressed cell proliferation and migration in ovarian cancer. Subsequent mechanism study revealed that circKIF4A acted as a competitive endogenous RNA (ceRNA) to promoted ovarian cancer progression by sponging miR-127 and upregulated the expression of Junctional adhesion molecule 3 (JAM3). Therefore, circKIF4A could be a novel biomarker and therapeutic target for ovarian cancer.

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Available abstract

Key concepts: Ovarian cancer, Gene knockdown, Cancer, Competing endogenous RNA, Cancer research, Biology, Tumor progression, Biomarker