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2020•Graduate Medical Education Research JournalOpen access

Comparing the Use and Survival Outcome of Stereotactic Radiosurgery and Stereotactic Radiation Therapy

Garrett Ostdiek-Wille, Saber Amin

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Abstract

Brain metastases are common in many types of cancer. Treatment for this condition is usually through surgical resection, whole brain radiation treatment (WBRT), stereotactic radiosurgery (SRS), or stereotactic radiation therapy (SRT). SRS (15 to 24 Gy in 1 fraction) and SRT (21, 24 or 30 Gy in 3 fractions or 25, 30 Gy in 5 fractions) have similar biological equivalent doses but differ in the number of treatments the radiation is delivered over. The objective of this study is to use national cancer database (NCDB) to examine the factors associated with receiving SRS as compared to SRT, and to compare overall survival between patients who received SRS to those who received SRT after adjusting for all potential prognostic factors. The two treatments were not found to have a significant difference in survival.

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What this paper is about

Brain metastases are common in many types of cancer. Treatment for this condition is usually through surgical resection, whole brain radiation treatment (WBRT), stereotactic radiosurgery (SRS), or stereotactic radiation therapy (SRT). SRS (15 to 24 Gy in 1 fraction) and SRT (21, 24 or 30 Gy in 3 fractions or 25, 30 Gy in 5 fractions) have similar biological equivalent doses but differ in the number of treatments the radiation is delivered over. The objective of this study is to use national cancer database (NCDB) to examine the factors associated with receiving SRS as compared to SRT, and to compare overall survival between patients who received SRS to those who received SRT after adjusting for all potential prognostic factors. The two treatments were not found to have a significant difference in survival.

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Available abstract

Brain metastases are common in many types of cancer. Treatment for this condition is usually through surgical resection, whole brain radiation treatment (WBRT), stereotactic radiosurgery (SRS), or stereotactic radiation therapy (SRT). SRS (15 to 24 Gy in 1 fraction) and SRT (21, 24 or 30 Gy in 3 fractions or 25, 30 Gy in 5 fractions) have similar biological equivalent doses but differ in the number of treatments the radiation is delivered over. The objective of this study is to use national cancer database (NCDB) to examine the factors associated with receiving SRS as compared to SRT, and to compare overall survival between patients who received SRS to those who received SRT after adjusting for all potential prognostic factors. The two treatments were not found to have a significant difference in survival.

Key concepts: Radiosurgery, Stereotactic radiotherapy, Stereotactic radiation therapy, Medicine, Radiation therapy, Radiology

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Comparing the Use and Survival Outcome of Stereotactic Radiosurgery and Stereotactic Radiation Therapy — Research Paper | ScholarLens